Saline was believed to have originated in the blue Indian cholera pandemic that swept Europe in 1831. William Brooke O'Shaughnessy , a recent graduate of the Faculty of Medicine of Edinburgh , suggested in an article in the medical journal The Lancet to inject cholera patients with highly oxygenated to treat the " universal stagnation of the venous system salts and rapid cessation of arterialization of blood " seen in severely dehydrated cholera patients . He found his treatment harmless in dogs, and his proposal was quickly adopted by the physician Thomas Latta in treating cholera patients to beneficial effect. In the following decades , variations and alternatives to Latta solutions have been tested and used in the treatment of cholera patients. These solutions contain a range of concentrations of chloride, sodium hydroxide , potassium carbonate, and phosphate . The breakthrough in achieving physiological concentrations was accomplished by Ringer in 1831 , when he determined the optimal salt concentrations to maintain the contractility of frog heart muscle tissue. Normal saline is considered a descendant of pre -Ringer solutions , ring findings have not been widely adopted and used until decades later . The term " normal saline " itself seems to have little historical basis , except for Hartog Jakob Hamburger 1882-1883 in vitro studies of the lysis of red blood cells that incorrectly suggested that 0.9% was the salt concentration in human blood (instead of 0.6 % , the actual concentration) .
ไม่มีความคิดเห็น:
แสดงความคิดเห็น